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Protein antibiotics have primarily evolved

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שאלה #105391

		Due to an evolutionary mistake
		As a by product of bacterial respiratory system
done		Due to the great inter-bacterial competition
		By horizontal gene transfer from yeast

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Bacteriocins are defined as

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שאלה #105392

		Antimicrobial entities produced by Eukaryotes
done		Ribosomaly synthesized protein antibiotics
		Small molecules with antimicrobial activity
		A new generation of clinically applied antibiotics

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Most bacteriocins we discussed target

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שאלה #105393

		Mostly marine archaea
		Mostly somatic Eukaryotic cells
		Mostly gram-negative bacteria
done		Mostly gram-positive bacteria

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What is Nisin?

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שאלה #105394

		A protein which mainly targets gram-negative bacteria
		A benzine ring active against E. coli and P. aeruginosa
		A peptide produced by E. coli to target gram-positive bacteria
done		A genetically encoded element with a broad range of activity

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Class 5 bacteriocins

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שאלה #105395

done		Are small, robust and cyclic
		Are sensitive to various proteases
		Are large, multidomain proteins
		Contain modified amino acids

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Most of the colicin structure

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שאלה #105396

		Helps it get out of the producing cell
		Serves as the killing domain
		Is part of a pre-protein which is cleaved prior entering the target cell
done		Is dedicated to bypass the cellular envelope of the target cell

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What are Colicins?

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שאלה #105397

		Small peptides active against gram-positive bacteria
done		Large protein antibiotics active against E. coli
		Proteins of medium size active against gram-positive bacteria
		Small molecules active against gram-negative bacteria

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What are Lantibiotics?

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שאלה #105398

		A type of gram-positive bacteria
		Gram-negative bacteria which produce peptides against gram-positive bacteria
done		Small peptides which are both produced and active against gram-positive bacteria
		Large proteins which contain modified amino acids

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What are Pediocines?

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שאלה #105399

done		Cations
		Anions
		Zwitterions
		Neutral

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Bacteriocins vs Small molecule antibiotics

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שאלה #105400

done		More likely to be specific
		Less likely to be specific
		More likely to be potent
		Less likely to be potent

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