שאלה | 49. How did the “Yamanaka factors” change our understanding of the Waddington landscape model?

49. How did the “Yamanaka factors” change our understanding of the Waddington landscape model?

		Under some conditions, cells can “roll back” differentiation all the way to pluripotency (de-differentiation)
		Under some conditions, cells can switch directly to an alternate fate (trans-differentiation)
		Once cells fully differentiate, they can never change their fate
		Cell fate decisions are made when cells respond to cues and choose between alternate “valleys”