שאלה | Mutations in Collagen 7 (COL7) gene lead to a severe pathology known as Epidermolysis Bullosa (EB) that affects the skin. Which of the below strategies would be suitable to model this pathology in vitro?

Mutations in Collagen 7 (COL7) gene lead to a severe pathology known as Epidermolysis Bullosa (EB) that affects the skin. Which of the below strategies would be suitable to model this pathology in vitro?

		Generation of induced pluripotent stem cells from COL7 mutated EB patientand healthy donors, differentiate the mutated and control cells into skin cells,and study skin organ formation in the dish
		Using CRISPR gene editing to mutate COL7 in embryonic stem cells (ESCs),differentiate the mutated and control ESCs into skin cells, and study skin organformation in the dish
		Cultivation of skin stem cells from COL7-mutated patients and healthy donors(in case that possible to obtain samples and grow the cells), differentiate themutated and control cells into skin cells, and study skin organ formation in thedish
		All the above answers (a-c) are correct