שאלה | What are the major pathophysiological features (described in class) of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) generated from Duchenne muscular dystrophy (DMD) patients?

What are the major pathophysiological features (described in class) of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) generated from Duchenne muscular dystrophy (DMD) patients?

		Increased contractile responsiveness to beta-adrenergic stimulation
		Decreased contractile responsiveness to beta-adrenergic stimulation
		Increase caffeine-induced calcium release from the sarcoplasmic reticulum inDMD iPSC-CM, compared to healthy iPSC-CM
		Increased spontaneous firing rate compared to healthy iPSC-CM