שאלה | Patient-specific induced pluripotent stem cells (iPSCs) were generated from a patient with inherited cardiac disorder and are differentiated to cardiomyocytes. How would one generate the best control cells?

Patient-specific induced pluripotent stem cells (iPSCs) were generated from a patient with inherited cardiac disorder and are differentiated to cardiomyocytes. How would one generate the best control cells?

		Use of gene editing technologies (CRISPR) to correct the mutation directly inthe cardiomyocytes derived from the patient's iPSCs
		Use of gene editing technologies (CRISPR) to correct the mutation in thepatient's iPSCs and then differentiating them into heart cells
		To generate iPSCs and differentiate them into cardiomyocytes from a healthyindividual who is not related at all to the studied patients
		To generate iPSCs and differentiate them into cardiomyocytes from a healthy(non-affected) family member
		To generate iPSCs and differentiate them into cardiomyocytes from anaffected patient with the same disease but is not related at all to the studiedpatient