עיכוב ה NKCC בחלק העולה של עניבת הנלה יגרום בעיקר ל:

As urine moves towards the more superficial portion of the thick ascending limb, NKCC2 is the major transport protein by which sodium is reabsorbed from the urine. This outward movement of sodium and the lack of water permeability in the thick ascending limb, creates a MORE diluted urine