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The signs of hypoglycemia are usually vague and often indistinguishable from those observed in other newborn conditions, such as hypocalcemia, septicemia, CNS disorders, or cardiorespiratory problems. Many newborns with hypoglycemia, however, are asymptomatic. Because the brain depends on glucose for energy, cerebral signs such as jitteriness, tremors, twitching, weak or high-pitched cry, lethargy, hypotonia, seizures, and coma are prominent. Other clinical manifestations are cyanosis, apnea, rapid and irregular respirations, sweating, eye rolling, and refusal to feed.