סוגיות נבחרות באפיגנטיקה 71121

Chronological age and biological age might not be the same since different individuals age at different rates

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מיין לפי

Chronological age and biological age are positively correlated.

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Estimating biological age of baboons was done based on DNA methylation levels in white blood cells. Following are some properties of white blood cells in animals. Which of these properties make white blood cells suitable to look for changes in DNA methylation over time?

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התשובה לפי צ'אטי, מסומנת במבחן תשובה לא נכונה לכן לא בטוח מה נכון

מיין לפי

Not stated directly in the text, but among the 573 sites used as a biological clock, about ¼ of the sites increased in methylation levels with age. Why do you think methylation levels tend to increase more than to decrease with age?

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Bisulfite sequencing detects DNA methylation by converting methylated cytosines into uracil.

1

מיין לפי

DNA methylation is a stable epigenetic mark. However, some methylation sites change methylation levels with age. In which cells/tissue type would you expect to find more changes in DNA methylation levels with aging?

1

מיין לפי

Relative to all methylation sites, there was a significant enrichment of "clock sites" in regions which were previously annotated as CpG islands and as promoters. Why do you think both types of sites were identified as enriched?

1

מיין לפי

Relative to all methylation sites, there was a significant enrichment of "clock sites" in genes that change their expression în response to bacterial infection (LPS). Why do you think that such immune system genes were enriched in "clock sites"?

1

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Some individuals were profiled for DNA methylation twice, at different ages. There was a correlation between chronological age and age predicted from methylation. However, why do you think that different individuals had different slope of lines connecting the early with the later points (Fig. 1 C,D)?

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מיין לפי

DNA methylation predicted chronological age of males with higher accuracy compared to females. This difference was mainly due to better accuracy of prediction at:

1

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סוגיות נבחרות באפיגנטיקה 71121

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Chronological age and biological age might not be the same since different individuals age at different rates

Chronological age and biological age are positively correlated.

Estimating biological age of baboons was done based on DNA methylation levels in white blood cells. Following are some properties of white blood cells in animals. Which of these properties make white blood cells suitable to look for changes in DNA methylation over time?

Not stated directly in the text, but among the 573 sites used as a biological clock, about ¼ of the sites increased in methylation levels with age. Why do you think methylation levels tend to increase more than to decrease with age?

Bisulfite sequencing detects DNA methylation by converting methylated cytosines into uracil.

DNA methylation is a stable epigenetic mark. However, some methylation sites change methylation levels with age. In which cells/tissue type would you expect to find more changes in DNA methylation levels with aging?

Relative to all methylation sites, there was a significant enrichment of "clock sites" in regions which were previously annotated as CpG islands and as promoters. Why do you think both types of sites were identified as enriched?

Relative to all methylation sites, there was a significant enrichment of "clock sites" in genes that change their expression în response to bacterial infection (LPS). Why do you think that such immune system genes were enriched in "clock sites"?

DNA methylation predicted chronological age of males with higher accuracy compared to females. This difference was mainly due to better accuracy of prediction at: