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Why is it important to keep transposons and repetitive elements in the genome in a silenced state?

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PRC complexes activity results in

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Regions in mammalian genomes that are considered as CpG islands (CGI) are characterized by higher CpG density and lower levels of DNA methylation.

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In germ cells, CGIs in promoters of germline genes should be

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Imprinted genes escape demethylation during early development and therefore,the information on silencing of these genes is inherited from parents to progeny

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Replacing canonical histones with variant ones can help transferring information on thetranscriptional state of a gene from mother to daughter cell.

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HOTAIR is an example for a IncRNA regulating gene expression in

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Replacement of H3 with H3.3 is a replication- independent process.

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The global DNA methylation pattern across the genome is placed

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Nucleosome free regions (NFRs) are positively correlated with intronic regions.

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