סוגיות נבחרות באפיגנטיקה 71121
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Which of the following modification is associated with repression of developmerntal genes expression?
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The first step of the rChlP protocol is cross-linking by formaldehyde. What is cross-linked at this step?
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In the paper, what type of molecule the antibodies that were used in the rChlP experiment recognized?
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iPSC are stem cells which are extracted from the inner cell mass (ICM) of blastocysts.
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In the paper, rChip experiments were done for EZH2, SUZ12, TPB and Rpb1. This is because all these are parts of the PRC2 complex that can potentially bind RNA
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In the paper, RNAse a treatment abolished PRC2-chromatin interactions for
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In the paper, based on the patterns of PRC2 binding to HOXB3 and c-Myc genes, what do you expect the expression levels to these genes in iPSCs will be?
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What information nascent RNA can add that mature RNA cannot to PRC2 binding to chromatin?
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According to the model proposed in the paper, PRC2 binding of RNA can contribute to the 3D organization of the chromatin inside the nucleus.
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According to the model proposed in the paper, what kind of IncRNAS are more commonly directing PRC2 to its target genes?
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