You are trying to develop a protocol to cause embryonic stem cells to differentiate into motor neurons. You find that if you add Sonic hedgehog (Shh) to your cultures at Day 4, then you do not get any motor neurons when you analyze the cultures at Day 8
However, if you add the molecule Noggin (an inhibitor of BMP signaling) to your cultures from Days 2-4, and then add Shh at Day 4, you do get motor neurons when you analyze the cultures at Day 8
Which of the following is the most likely to be true?